Jul 06, 2017 in zeises anion, this rotational barrier has not been assessed. Molecular geometry of zeises salt alkene coordination. A new inelastic neutron scattering study of zeise s salt, kptc2h4cl3, and a more confident assignment of the vibrational frequencies. The salt reference book provides the conceptual background of language sample analysis, practical guidelines for using salt, and extensive appendices for quick reference to all the database protocols, transcription conventions, special coding, and more. Oehha is subject to the california public records act and other laws that require the release of certain information upon request. Zeises salt as powerful platinating agent for proteins. Zeise s salt, anhydrous and monohydrate, has been prepared by a new method similar to the original method used by zeise. Handwritten notes pdf study material for all engineering chemistry students. Fragments are singly charged except when noted otherwise. Access the applications web page to download a tutorial for salt where you will find detailed information about how to use the program. Files are available under licenses specified on their description page. The growth inhibitory effects of the synthesized substances were investigated in vitro against colon carcinoma ht29 and breast cancer mcf7 cells. Here, we discuss the interactions of an organometallic complex consisting of an acetylsalicylic acid asa moiety attached to a ptii center via an alkenol linker in a zeises salttype coordination asabutenptcl3 with model peptides angiotensin.
Binding of zeises salt via a methylene spacer to the carboxylic group of asa analogously to the design of coass see figure 1 increased the stability, as well as the cox inhibitory potency. See how easy the software is to use and how much great data you can pull out of a short language sample. The most famous platinum complex in anticancer therapy by far is cisplatin, which was. This page was last edited on 19 august 2014, at 11. Free fulltext pdf articles from hundreds of disciplines, all in one place topdown mass spectrometry reveals multiple interactions of an acetylsalicylic acid bearing zeises salt derivative with peptides pdf paperity. Synthesis, characterization of mono and bisylidic ptii derivatives and xray crystal structure of the ptcl 2 chcoch 3 pph 2 oc 6 h 4 pph 3 ch 2 coch 3 complex, inorganica chimica acta on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your. Media in category zeise s salt the following 11 files are in this category, out of 11 total. Zeises salt, potassium trichloroethyleneplatinateii, is the chemical compound with the. A pdf copy of this book is included with the software accessible from the help menu. Nov 11, 2019 zeises salt, kptc 2 h 4cl 3, was the first characterized organometallic compound. With the aim to design new biologically active bioinorganic drugs of aspirin, whose mode of action is based on the inhibition of the cyclooxygenasecox enzymes, derivatives of zeises salt were synthesized in this structureactivity relationship study. Click on a datetime to view the file as it appeared at that time. Journal of organometallic chemistry elsevier sequoia sa lausanne 787 printed in the netherlands the reaction of cyclopropane with zeise s salt david basset brown bell telephone laboratories, murray hill, newv jersey 07974 u.
Zeises salt synthesized in 1827 kptc2h4cl3 h2o confirmed to have h2cch2 as a ligand in 1868 structure not fully known until 1975 nico4 synthesized in 1890 grignard reagents xmgr synthesized about 1900 accidentally produced while trying to make other compounds utility to organic synthesis recognized early on. It was one of the very first organometallic compounds to be prepared. The biological activity of zeises salt and its derivatives. The vibrational spectra of several platinumethylene complexes. Neutron diffraction study of the structure of zeises salt. Ripley deep water this sweet sickness the glass cell a suspension of mercy ripley under ground a dogs ransom. A square planar ptcl3c2h4 molecule is shown in figure 5. The addition of cyclopropane to h2ptcl6 yields the ptcyclopropane complex ptci2c3h6, whereas addition of cyclopropane to zeises acid hptcl3c2h4 in. Zeise s salt reacts with water to replace a chloro ligand by aquo, upon which base hydrolysis decomposes to give acetaldehyde as figure 4 synergic s and pbond formation in zeise s salt. A redetermination of the crystal and molecular structure of. Most recently, the asa moiety was linked to ptii via an alkenol spacer in a zeises salttype coordination 19, and the influence of the spacer.
William christopher zeise and his platinum complexes pdf. Deviation from the transeffect in ligandexchange reactions of zeises ions ptcl3c2h4. Zeises salt is synthesized by reaction between k 2 ptcl 4 and ethene, with a sncl 2 catalyst. Meieranz s1, stefanopoulou m, rubner g, bensdorf k, kubutat d, sheldrick ws, gust r. Topdown mass spectrometry reveals multiple interactions of. Photolysis of zeise salt in aqueous solution request pdf. However, we demonstrated that zeises salt is pharmacologically active as it inhibited the cox isoenzymes during an incubation time of 10 min. At that time, zeise had no way of determining the structure of his new compound, but today it is known that the structure contains an ethylene molecule h 2 cch 2 attached through both carbon atoms to the central platinum pt atom.
If you submit this form, please be aware that your name and email may be provided to third parties. Zeises salt potassium trichloroethyleneplatinateii monohydrate1. Crown ether adducts of olefin complexes of zeises salt. All structured data from the file and property namespaces is available under the creative commons cc0 license. Lauren zeise health hazard assessment, the california environmental protection agency or the state of california office of environmental health hazard assessment california epa june 14, 2012 systems biology informed risk assessment nrc emerging sciences for environmental health decisions. The biological activity of zeises salt and its derivatives article in angewandte chemie international edition in english 549 january 2015 with 44 reads how we measure reads.
He also performed pioneering studies in organosulfur chemistry, discovering the xanthates in 1823. The ic50 values of the new derivatives ranged from 30 to 50 m, whereas neither zeises salt itself nor asa showed any antiproliferative activity at the used concentrations. William christopher zeise october 15, 1789 november 12, 1847 was a danish organic chemist. Zeises salt reacts with water to replace a chloro ligand by aquo, upon which base hydrolysis decomposes to give acetaldehyde as figure 4 synergic s and pbond formation in zeises salt.
Norton strangers on a train the blunderer the talented mr. Infrared spectra and normal coordinate analysis of metalolefin. It was published in 18251830 in the middle of a fight between dumas on the one hand and berzelius and liebig on the other, who defended the etherin ethylene and radical theories, respectively. Feb 23, 2015 the biological activity of zeises salt and its derivatives. Zeises salt, kptc2h4cl3, anhydrous and monohydrate and. Hcd fragmentation of atpt 2 clc 2 h 4 2 mz 888 with z 2. Zeise s salt, ptc2h4cl3, is the first ptii squareplanar complex to exhibit an antithermal photoreaction, photoaquation of ethylene in the present case. Historical developments is often referred to as zeises salt.
In zeise s anion, this rotational barrier has not been assessed. Read reactivity of carbonyl stabilized ylides with zeises salt. The cc stretching frequency in zeises salt, which has heretofore always been taken as the weak infrared band near 1520 cm. Molecular geometry of zeises salt alkene coordination complex. Crown ether adducts of olefin complexes of zeises salt type. Zeises salt, ptc2h4cl3, is the first ptii squareplanar complex to exhibit an antithermal photoreaction, photoaquation of ethylene in the present case. Topdown mass spectrometry reveals multiple interactions of an. Then open one of the sample files and generate several analyses. It was discovered by william christopher zeise, a professor at the university of copenhagen, who prepared this compound in 1830 while investigating the reaction of ptcl 4 with boiling ethanol. It is made by reacting potassium chloride with platinum dichloride in ethanol and was one of the first, if not the first, organometallic complex to be made. Highlights mlct excitation of aqueous zeise salt leads to the wellknown release of ethylene about 10% of the released ethylene undergoes a photohydration to ethanol pt ii c 2 h 4cl 3. The photolysis of aqueous zeise salt essentially leads to the release of ethylene, but about 10% undergo a photohydration which is initiated by mlct excitation. Zeise s salt, kptc 2 h 4cl 3, was the first characterized organometallic compound.
A redetermination of the crystal and molecular structure of zeises salt, kptcl 3. Zeises salt, kc2h4ptcl3, has been known since 18301, and dichlorobisethylene. Zeise, liebig, jensen, huckel, dewar, and the olefin. The crystal and molecular structure of zeises salt, kptcl. Synthesis and biological evaluation of zeises salt.
Read zeise s salt studied by high resolution solid state c cpmas and 1 h speda nmr spectroscopy, chemical physics letters on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Codplatinum dichloride, cyclooctadieneptcl 2, derived from platinumii chloride and 1,5cyclooctadiene, is a common platinumii alkene complex. Received march th, 1970 summary the addition of cyclopropane to h2ptcl6 yields the pt. Zeises salt, potassiumtrichloroetheneplatinateii, is the chemical complex with the formula kptcl3c24h2o. Synergistic effects and promising anticancer activities encourage the combination of nonsteroidal antiinflammatory drugs with metallodrugs. Reactivity of carbonyl stabilized ylides with zeises salt. Molecular geometry of zeises salt free download as powerpoint presentation. Zeises salt was one of the first organometallic compounds to be reported. Zeise s salt was one of the first organometallic compounds to be reported. Pdf zeises salt, kptc2h4cl3, anhydrous and monohydrate.
The infrared and laser raman spectra of the anhydrous zeise s salt together with the infrared spectra of the deutero and bromo analogs, are reported and discussed. The reaction of cyclopropane with zeises salt sciencedirect. At that time, zeise had no way of determining the structure of his new compound, but today it is known that the structure contains an ethylene molecule h2cch2 attached through both carbon atoms to the central platinum pt atom. He is best known for synthesising one of the first organometallic compounds, named zeises salt in his honour. The iucr is a scientific union serving the interests of crystallographers and other scientists employing crystallographic methods.